RPN1a, a 26S proteasome subunit, is required for innate immunity in Arabidopsis

The Plant Journal : for Cell and Molecular Biology
Chunpeng YaoDingzhong Tang

Abstract

Accumulating evidence shows that proper degradation of proteins that affect defense responses in a positive or negative manner is critical in plant immunity. However, the role of plant degradation systems such as the 26S proteasome in plant immunity is not well understood. Loss-of-function mutations in EDR2 (ENHANCED DISEASE RESISTANCE 2) lead to increased resistance to the adapted biotrophic powdery mildew pathogen Golovinomyces cichoracearum. To study the molecular interactions between powdery mildew pathogen and Arabidopsis, we performed a screen for suppressors of edr2 and found that mutation in the gene that encodes RPN1a, a subunit of the 26S proteasome, suppressed edr2-associated disease resistance phenotypes. In addition, RPN1a is required for edr1- and pmr4-mediated powdery mildew resistance and mildew-induced cell death. Furthermore, we show that rpn1a displayed enhanced susceptibility to the fungal pathogen G. cichoracearum and to virulent and avirulent bacterial Pto DC3000 strains, which indicated that rpn1a has defects in basal defense and resistance (R) protein-mediated defense. RPN1a-GFP localizes to both the nucleus and cytoplasm. Accumulation of RPN1a is affected by salicylic acid (SA) and the rpn1a mutant has ...Continue Reading

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Citations

Feb 14, 2015·Plant Physiology and Biochemistry : PPB·Dashi YuXuanming Liu
Oct 21, 2016·Plant Physiology and Biochemistry : PPB·Dashi YuXuanming Liu
Feb 5, 2019·Journal of Experimental Botany·Jose Salguero-Linares, Núria S Coll
Aug 1, 2019·Plant, Cell & Environment·Fa-Qing Xu, Hong-Wei Xue
Jun 2, 2020·Genetics and Molecular Biology·Graziéle R SasseronAlisson F Chiorato
Nov 19, 2015·Frontiers in Plant Science·Justin LeeDierk Scheel
Mar 31, 2017·Molecular Breeding : New Strategies in Plant Improvement·F K S YeoT C Marcel
Jul 14, 2017·Plant Biotechnology Journal·Javier A MiretPaul P Dijkwel

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