PMID: 8615360May 1, 1996Paper

RRR-alpha-tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus

The American Journal of Clinical Nutrition
C J FullerI Jialal

Abstract

Patients with diabetes mellitus have an increased risk of premature atherosclerosis, which may be due in part to increased oxidizability of low-density lipoprotein (LDL). Numerous studies have shown that alpha-tocopherol can reduce the oxidative susceptibility of LDL in normoglycemic subjects; however, there are few studies in persons with diabetes. In addition, alpha-tocopherol may reduce the extent of protein glycation. Therefore, the objective of the present study was to assess the effect of RRR-alpha-tocopheryl acetate supplementation on LDL oxidizability and protein glycation in persons with diabetes without evidence of vascular disease. Twenty-eight persons with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) were randomly assigned to receive either placebo or 1632 mg (1200 IU) RRR-alpha-tocopherol/d, as tocopheryl acetate, for 8 wk. Plasma and LDL antioxidant concentrations and LDL oxidizability were assessed at both 0 and 8 wk. Plasma and LDL concentrations of alpha-tocopherol were significantly increased in the supplemented group only. Compared with the placebo group, the alpha-tocopherol-supplemented group had significant reductions in LDL oxidizability at 8 wk, as shown ...Continue Reading

Citations

Jan 1, 1996·International Journal of Clinical & Laboratory Research·S Devaraj, I Jialal
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·S DevarajI Jialal
Aug 6, 2004·Endocrine Reviews·Andrea M VincentEva L Feldman
Jul 22, 2005·Current Diabetes Reports·Xinhua Chen, Theresa O Scholl
Nov 5, 2003·The American Journal of Clinical Nutrition·Jane E UpritchardSheila A Wiseman
Mar 19, 2013·Journal of Lipid Research·Maret G Traber
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Joíza Lins Camargo, Jorge Luiz Gross
Jun 14, 2008·The Journal of Pharmacy and Pharmacology·Francisco J RupérezEmilio Herrera
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ryan BradleyLeanna J Standish
Oct 8, 1999·Journal of the American College of Nutrition·J W AndersonP R Oeltgen
Oct 2, 2008·The British Journal of Nutrition·S Honarbakhsh, M Schachter
Feb 17, 1998·Annals of Clinical Biochemistry·F P Woodford, T P Whitehead
Jul 18, 2001·Journal of Diabetes and Its Complications·B Lipinski
Aug 31, 2002·Diabetes/metabolism Research and Reviews·P J DickinsonA J M Boulton
Jul 13, 1999·The Journal of Laboratory and Clinical Medicine·W A Oranje, B H Wolffenbuttel
Jun 4, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jorge L Ble-CastilloJuan C Díaz-Zagoya
Sep 11, 2007·Molecular Aspects of Medicine·Adelina Munteanu, Jean-Marc Zingg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.