PMID: 9423922Jan 10, 1998Paper

(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo

Neuropharmacology
S J Martin, R G Morris

Abstract

The effects of the metabotropic glutamate receptor antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) on the induction of long-term potentiation (LTP) in the dentate gyrus were examined under urethane anaesthesia in vivo. In experiment 1, bilateral intraventricular infusion of either 20 mM or 200 mM (R,S)-MCPG (5 microl each side) failed to block LTP in the perforant path-granule cell projection, relative to vehicle-infused controls; 30 mM D-AP5 (5 microl each side) infused in the same way as MCPG completely blocked LTP. Experiment 2, in which the contralateral perforant path-dentate gyrus pathway was used as a non-tetanized control, revealed that slight baseline changes induced by MCPG infusion were transient; again no block of LTP was obtained. The efficacy of mGluR blockade was confirmed in experiment 3, in which MCPG antagonized an increase in spontaneous activity induced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD). In experiment 4, significant depotentiation was induced by low frequency stimulation (5 Hz for 1 min) given 2 min after high frequency tetanization, but MCPG remained ineffective in blocking LTP after a second tetanus. In experiment 5, increasing the period of low frequency stimulation f...Continue Reading

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Citations

Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini
Jul 8, 1999·Current Opinion in Neurobiology·Z A BortolottoG L Collingridge
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie
Dec 30, 2008·Pharmacological Reviews·Francesco FerragutiFerdinando Nicoletti
Jan 13, 2004·Physiological Reviews·M A Lynch

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