Rs2910164 in microRNA‑146a confers an elevated risk of depression in patients with coronary artery disease by modulating the expression of NOS1

Molecular Medicine Reports
Xinling ZhangQiang Li

Abstract

Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence has shown that single nucleotide polymorphisms located in pre‑microRNA (miRNA) or mature miRNA may modify various biological processes and affect the process of carcinogenesis, and the downregulation of neuronal nitric oxide synthase 1 (NOS1) can induce depression. It has been shown that NOS1 is the target gene of miR‑146a, and that the rs2910164 G/C polymorphism can downregulate the expression of miR‑146a. In the present study, computational analysis was used to identify the target of miR‑146a, and a luciferase reporter assay system was used to validate NOS1 as a target gene of miR‑146a. In addition, U251 cells were treated with miR‑146a mimics/inhibitors to verify the negative regulatory association between miR‑146a and NOS1. Reverse transcription‑quantitative polymerase chain reaction analysis and western blot analysis were used to estimate the mRNA expression of NOS1 and the expression of miR‑146a. The results showed that the 'seed sequence' was located within the 3'‑untranslated region of NOS1 by searching an online miRNA database (www.mirdb.org), and the lucifer...Continue Reading

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Jun 11, 2019·Frontiers in Psychology·Dhaksshaginy RajalingamJohannes Gjerstad
Jul 3, 2021·International Journal of Molecular Sciences·Sylwia CiesielskaJoanna Rzeszowska-Wolny

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