rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Obesity Surgery
Laura J Rasmussen-TorvikPhilip Greenland

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

References

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Citations

Jun 12, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hiba Shanti, Firas Obeidat
Jan 12, 2017·International Journal of Epidemiology·Paul W Franks
Dec 13, 2017·Gastroenterology Report·Xulong SunShaihong Zhu
Nov 8, 2019·RNA Biology·Shreya Ahana Ayyub, Umesh Varshney
Sep 7, 2018·JCI Insight·Juan de Toro-MartínMarie-Claude Vohl
Oct 12, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Laura BoswellJosep Vidal
Jan 4, 2020·Obesity Surgery·E A KatsareliG V Dedoussis
Oct 10, 2020·Metabolism: Clinical and Experimental·Robert DentMary-Ellen Harper
Aug 10, 2021·Obesity Surgery·Sapana R GuptaAriana M Chao

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