Rs739837 affects the severity of asthma by disrupting the binding of microRNA-885

Personalized Medicine
Guan-Shan YangJing-Lin Ou

Abstract

Aim: This study investigated the molecular mechanism underlying the involvement of miR-885 in the signaling pathways of VDR. Results: Based on their rs739837 genotype, the subjects were divided into a case group and a control group. Logistic regression was carried out to study the impact of rs739837 genotypes on the severity of asthma, and it was found that the minor allele (T) of rs739837 significantly increased the severity of asthma. Using a luciferase assay, VDR was confirmed as a miR-885 target, with a negative regulatory relationship established between VDR and miR-885. Conclusion: The findings of this study demonstrated that VDR is an miR-885 target, while the presence of rs739837 minor allele (T) in miR-885 interferes with the interaction between miR-885 and VDR to affect the severity of asthma.

References

Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·I NemereB D Boyan
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A W Norman
Apr 25, 2000·In Vitro Cellular & Developmental Biology. Animal·E T Obi-TabotM F Holick
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Jun 14, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarabjit S PhokelaJoseph L Alcorn
Jan 24, 2008·Nature Clinical Practice. Endocrinology & Metabolism·John S Adams, Martin Hewison
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sif HansdottirGary W Hunninghake
May 23, 2009·Cell Death and Differentiation·H Hermeking
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Dec 29, 2010·Pediatrics·Carlos A CamargoUNKNOWN New Zealand Asthma and Allergy Cohort Study Group
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs

❮ Previous
Next ❯

Citations

Dec 31, 2020·International Journal of Molecular Sciences·Stephen M NiemiecCarlos Zgheib

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
transfection

Software Mentioned

SPSS13
Analysis

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.