PMID: 25773791Mar 17, 2015Paper

Rs895819 within miR-27a might be involved in development of non small cell lung cancer in the Chinese Han population

Asian Pacific Journal of Cancer Prevention : APJCP
Ji-Yong MaWei Gu

Abstract

MicroRNA-27a (miR-27a) is deemed to be an oncogene that plays an important role in development of various cancers, and single nucleotide polymorphism (SNP) of miR-27a can influence the maturation or aberrant expression of hsa-miR27a, resulting in increased risk of cancer and poor prognosis for non-small cell lung cancer (NSCLC). This study aimed to assess the effects of rs895819 within miR-27a on susceptibility and prognosis of NSCLC patients in 560 clinical confirmed cases and 568 healthy check-up individuals. Adjusted odds/hazard ratios (ORs/HRs) and 95% confidential intervals (CIs) were calculated to evaluate the association between rs895819 and the risk and prognosis of NSCLC. The results showed that allele A and genotype GG of rs895819 were significantly associated with an increased risk of NSCLC (38.9% vs 30.8%, adjusted OR=1.26, 95%CI=1.23-1.29 for allele G vs A; 18.1% vs 11.7%, adjusted OR=1.67, 95%CI=1.59-1.75 for genotype GG vs AA). Moreover, positive associations were also observed in dominant and recessive models (53.7% vs 49.9%, adjusted OR=1.17, 95%CI=1.13-1.20 for GG/AG vs AA; 18.1% vs 11.7%, adjusted=1.65, 95%CI=1.58-1.73). However, no significant association was found between rs895819 and the prognosis of NSCLC...Continue Reading

References

Jan 8, 2009·American Journal of Epidemiology·Santiago RodriguezIan N M Day
Nov 19, 2009·Breast Cancer Research and Treatment·Rongxi YangBarbara Burwinkel
Dec 5, 2009·Digestive Diseases and Sciences·Hongwei ZhangXiushan Zheng
Nov 13, 2010·Journal of Cellular and Molecular Medicine·Dan-Dan FengYue-Qin Chen
Mar 9, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mi Jeong HongJae Yong Park
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weibo PanZhaoming Ye
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yan FengPatrick C Ma
Aug 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaohong Fan, Zhijun Wu
Aug 1, 2014·Diagnostic Pathology·Zaiqiu WangSanyuan Hu
Oct 11, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ricardo AparicioAna Busturia
Oct 22, 2014·World Journal of Methodology·Pooja JoshiMichela Garofalo
Oct 30, 2014·Nature Communications·Rajesha RupaimooleAnil K Sood

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Citations

Aug 19, 2016·International Journal of Molecular Sciences·Rocío BarragánDolores Corella
Jan 25, 2017·Gastroenterology Research and Practice·Nina Nayara Ferreira MartinsDanielle Queiroz Calcagno
Jan 9, 2019·Frontiers in Oncology·Han-Xi DingQian Xu
Jul 28, 2020·Journal of Clinical Laboratory Analysis·Shulong ZhangQuan Wang

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