Rsf-1 expression in rectal cancer: with special emphasis on the independent prognostic value after neoadjuvant chemoradiation

Journal of Clinical Pathology
Ching-Yih LinShang-Hung Chen

Abstract

Neoadjuvant chemoradiation therapy (CRT) is an increasingly used therapeutic strategy for rectal cancer. Clinically, it remains a major challenge to predict therapeutic response and patient outcome after CRT. Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling and confers tumour aggressiveness and predicts therapeutic response in certain carcinomas. However, the expression of Rsf-1 has never been reported in rectal cancer. This study examined the predictive and prognostic impacts of Rsf-1 expression in patients with rectal cancer following neoadjuvant CRT. Rsf-1 immunoexpression was retrospectively assessed for pre-treatment biopsies of 172 rectal cancer patients without initial distant metastasis. All of them were treated with neoadjuvant CRT followed by surgery. The results were correlated with the clinicopathological features, therapeutic response, tumour regression grade and metastasis-free survival (MeFS), local recurrent-free survival and disease-specific survival. Present in 82 cases (47.7%), high-expression of Rsf-1 was associated with advanced pre-treatment tumour status (T3, T4, p=0.020), advanced post-treatment tumour status (T3, T4, p<0.001) and infe...Continue Reading

Citations

Jan 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Feng TianShang-Hung Chen
Jan 24, 2009·Cell Division·Lin-Yu Lu, Xiaochun Yu
May 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming-Jen SheuLi-Jung Ma
Aug 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi-Ying LeeChung-Hsi Hsing
Feb 5, 2013·The Journal of Pathology·Jim Jinn-Chyuan SheuIe-Ming Shih
Dec 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Chun ZhaoDong-Yi Tong
Aug 12, 2014·World Journal of Gastroenterology : WJG·Aoife Maguire, Kieran Sheahan
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Aug 17, 2019·International Journal of Surgical Pathology·Giuseppe N FanelliMatteo Fassan

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