RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer

BioMedicine
Xiangyu WangLi Sun

Abstract

Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer. RSF-1 expression in cancer tissues was analyzed by immunohistochemical staining followed by statistical analysis with SPSS. Anti-RSF-1 studies were performed by treating cells with specific siRNA or a dominant mutant form (RSF-D4). RSF-1 expression correlates with cancer progression that strongly-positive staining can be found in 67.7% carcinomas and 66.7% CIN lesions, but none in normal tissues. Such overexpression also associated with increased tumor size, poor differentiation, higher nodal metastasis and advanced clinical stages. Kaplan- Meier analysis confirmed that cancer patients with high RSF-1 levels exhibited a significantly shorter survival time than those with low RSF-1 levels. Downregulation of RSF-1 by siRNA silencing or RSF-D4 reduced cell growth and increased drug sensitivity toward paclitaxel treatment in HeLa cells. RSF-1 participates in the tumor progression of cervical cancer and could be considered as an early prognostic marker for cancer development and clinical outcome. Therapies based on anti-RSF-1 activity may be beneficial for patients...Continue Reading

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Citations

Jul 10, 2019·International Journal of Molecular Sciences·Po-Chun ChenChih-Hsin Tang
Apr 14, 2020·Expert Opinion on Drug Delivery·Shahin AghamiriHossein Ghanbarian
May 21, 2020·Scientific Reports·Agustín González-Reymúndez, Ana I Vázquez
Feb 14, 2021·Journal of Cellular Physiology·Kevin Chih-Yang HuangKun-San Clifford Chao
Oct 24, 2020·ACS Combinatorial Science·Milad AshrafizadehPooyan Makvandi
May 25, 2021·Computational and Structural Biotechnology Journal·Desh Deepak SinghDharmendra Kumar Yadav

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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