RSH/SLO (Smith-Lemli-Opitz) syndrome: designing a high cholesterol diet for the SLO syndrome

American Journal of Medical Genetics
P B Acosta

Abstract

A high cholesterol diet has been suggested to help prevent the poor reproductive outcomes found in heterozygote carriers of fetuses affected with the Smith-Lemli-Opitz (SLO) syndrome. The theory has also been presented that a high cholesterol medical food may enhance myelination of the central nervous system of the infant and prevent demyelination in the child and adult with SLO. Clinical studies are required to test this hypothesis and to determine the optimal composition of such medical foods. FDA requires proof of efficacy and controls nutrient composition, ingredients, and label claims of medical foods.

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Related Concepts

Multiple Congenital Anomalies
Blood - Brain Barrier Anatomy
Brain Chemistry
Epicholesterol
Cholesterol, Dietary
Product Approval
Clinically Isolated Syndrome, CNS Demyelinating
Food Analysis
Food, Fortified
Infant Food

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