RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities.

Journal of the American Chemical Society
Srinivas RapireddyDanith H Ly

Abstract

Macrocyclic peptides with multiple disulfide cross-linkages, such as those produced by plants and those found in nonhuman primates, as components of the innate immunity, hold great promise for molecular therapy because of their broad biological activities and high chemical, thermal, and enzymatic stability. However, for some, because of their intricate spatial arrangement and elaborate interstrand cross-linkages, they are difficult to prepare de novo in large quantities and high purity, due to the nonselective nature of disulfide-bond formation. We show that the disulfide bridges of RTD-1, a member of the θ-defensin subfamily, could be replaced with noncovalent Watson-Crick hydrogen bonds without significantly affecting its biological activities. The work provides a general strategy for engineering conformationally rigid, cyclic peptides without the need for disulfide-bond reinforcement.

References

Jul 20, 1990·Science·B M OliveraL J Cruz
Jun 1, 1967·The Journal of Physical Chemistry·E B Nielsen, J A Schellman
Nov 4, 1994·Science·P E DawsonS B Kent
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P TamK W Chiu
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·C JenningsM Anderson
Jan 25, 2002·Nature·Michael Zasloff
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexander M ColeRobert I Lehrer
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Sara SinhaBetsy C Herold
Sep 2, 2003·Nature Reviews. Immunology·Tomas Ganz
Feb 6, 2004·Nature Reviews. Drug Discovery·Peter KirkpatrickJohn Lebbos
Sep 17, 2004·Nature Reviews. Microbiology·Robert I Lehrer
Mar 18, 2006·Science·David J Craik
Jun 23, 2006·The Journal of Biological Chemistry·Wei WangRobert I Lehrer
Aug 3, 2006·Journal of the American Chemical Society·Anca Dragulescu-AndrasiDanith H Ly
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arik MakovitzkiYechiel Shai
Dec 7, 2007·Chembiochem : a European Journal of Chemical Biology·Afaf H El-SagheerTom Brown
Dec 28, 2007·Antimicrobial Agents and Chemotherapy·Dat TranMichael E Selsted
Aug 29, 2009·Science·Michael A Fischbach, Christopher T Walsh
Feb 17, 2010·Journal of the American Chemical Society·Ryan HiliAndrei K Yudin
Apr 14, 2010·Molecular BioSystems·Wei HeCatalina Achim

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Citations

Aug 1, 2014·Angewandte Chemie·Anne C Conibear, David J Craik
Nov 28, 2013·Current Opinion in Hematology·Le Zhao, Wuyuan Lu
Apr 10, 2018·Chemical Science·Jessica SayersNicolas Winssinger
Aug 14, 2020·Chemical Reviews·Rasha JwadLuke Hunter
Jul 16, 2014·ACS Applied Materials & Interfaces·Liwei HuiLihua Yang

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