rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression

Psychiatry Research
Lin ZhaoJinggui Song

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been widely used to treat depression. The mechanistic basis for the effects of rTMS is not well understood, although previous studies have suggested that it involves the regulation of hypothalamic-pituitary-adrenocortical (HPA) axis and protection of hippocampal neurons. We investigated this in the present study using a chronic unpredictable mild stress (CUMS) paradigm in Sprague-Dawley rats. The rats were subjected to rTMS for 15 consecutive days, and body weight, sucrose consumption, and locomotor activity were evaluated. B cell lymphoma-2-associated X protein (Bax) expression was assessed by immunohistochemistry; cell morphology was examined by Nissl staining; and adrenocorticotropic hormone (ACTH) and cortisol (CORT) levels in the hippocampus were measured by enzyme-linked immunosorbent assay. CUMS decreased body weight and sucrose consumption in rats along with horizontal/vertical distance traveled in the open field test. Rats subjected to CUMS also showed increased levels of Bax as well as ACTH and CORT; the hippocampal neurons in these animals had abnormal morphology and were reduced in number. rTMS reversed these changes and improved depression-like behaviors. Thus...Continue Reading

Citations

Jan 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mathieu NolletRaphaelle Winsky-Sommerer
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Tianyu ZouCheng Mei
Mar 4, 2020·Brain, Behavior, and Immunity·Andrew J Perrin, Carmine M Pariante
Jul 17, 2021·Neural Regeneration Research·Mohammad UzairShahid Bashir
Jan 6, 2021·ACS Chemical Neuroscience·Abdul Haque AnsariSuneel Kumar
Aug 24, 2021·Ecotoxicology and Environmental Safety·Zhongbi PengChun Xie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.