RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements

The Breast : Official Journal of the European Society of Mastology
Chih-Jen HuangHung-Yi Chuang

Abstract

Various clinician-assessed scoring criteria have been used to grade acute radiation dermatitis. However, it is not known whether these scoring criteria correlate with changes in objective skin biophysical parameters and patient-reported symptoms following radiotherapy. We seek to correlate three different clinician-assessed scoring criteria with skin biophysical changes and patient-reported symptoms in breast cancer patients undergoing radiotherapy. A prospective cohort study was performed in a university hospital medical center. The severity of acute radiation dermatitis in 101 breast cancer patients was graded using the RTOG, CTCAE and WHO clinical scoring criteria. We also measured various skin biophysical parameters (skin blood flow, pigmentation, hydration, and pH) by non-invasive techniques before and after radiotherapy. Patient-reported breast symptoms (pain, itching, local heat, and tightness) were evaluated using a questionnaire. The three different clinician-assessed scoring criteria correlated most strongly with changes in cutaneous blood flow following radiotherapy for breast cancer (correlation coefficient 0.70 for RTOG, 0.68 for CTCAE, and 0.50 for WHO). All three scoring criteria also showed moderate correlation ...Continue Reading

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Citations

Nov 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Amparo González SanchisJose Luis López Torrecilla
May 18, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M GarnierL Machet
Jul 25, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jakub PazdrowskiWojciech Golusiński
Sep 8, 2016·Experimental and Therapeutic Medicine·Sun-Young LeeDong-Hyu Cho
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May 5, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroshi SekineKeiko Nozawa
Nov 19, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Tara BehroozianEdward Chow
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Mar 28, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tara BehroozianEdward Chow
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Nov 19, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y HuangM Algara

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