RU 486 mediated leukocytic inflammatory reaction at the utero-placental interface.

Asia-Oceania Journal of Obstetrics and Gynaecology
M J SinosichG D Hodgen

Abstract

Placentae obtained from RU 486 treated cynomolgus monkeys, with successful pregnancy outcome, could not be distinguished, by microscopic or macroscopic examination, from normal placental morphology of untreated females. However, circulating PAPP-A levels were markedly depressed in RU 486 treated (114.8 +/- 13.1 IU/l) than in control animals (477.2 +/- 150 IU/l), suggesting compromised placental physiology. Microscopic examination of placental tissue obtained from animals with fetal demise, after RU 486 administration, revealed pathological changes. When fetal demise occurred recently (less than 24 h), active villus destruction by infiltrating polymorphonuclear leukocytes was readily observed. Whereas aqueous extracts of placentae, whether obtained by cesarean section or spontaneous delivery, inhibited neutrophil elastase (HGE) activity, extracts of placenta being degraded by host phagocytic-proteolytic defense system were rich in HGE activity. Thus suggesting that parturition was not mediated by leukocyte lysosomal proteases, such as HGE, and that hemochorrially implanted placentae produce PAPP-A, a specific inhibitor of HGE. Administration of RU 486 decreased placental PAPP-A production and secretion, culminating with a neutro...Continue Reading

References

Jan 1, 1987·Journal of Reproductive Immunology·M J Sinosich, D M Saunders
Jan 1, 1987·Archives of Gynecology and Obstetrics·E E BaulieuD Philibert
Jul 1, 1988·American Journal of Obstetrics and Gynecology·J P WolfG D Hodgen
Jan 1, 1986·Methods in Enzymology·C J van Oss
Sep 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A A Haspels
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M J SinosichD M Saunders

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Citations

Sep 9, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezRoberto Romero

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