Ru-Catalyzed asymmetric transfer hydrogenation of α-trifluoromethylimines

The Journal of Organic Chemistry
Meng WuGuohua Liu

Abstract

Enantioselective transformation of strong electron-withdrawing acyclic α-trifluoromethylimines to α-trifluoromethylamines through a ruthenium-catalyzed asymmetric transfer hydrogenation has been developed. The method described here is a facile catalytic process with sodium formate as a hydrogen resource and water-dimethylformamide as a cosolvent. The benefit of this enantioselective transformation affords a series of chiral α-trifluoromethylamines with high yields and excellent enantioselectivities (93-99% ee) under mild reaction conditions.

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Citations

Jun 2, 2016·The Journal of Organic Chemistry·Thomas JohnsonMark Lautens
Aug 31, 2016·Topics in Current Chemistry·Martin Wills
Aug 26, 2015·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Francisco Foubelo, Miguel Yus
Jul 27, 2021·ACS Catalysis·Chibueze I Onyeagusi, Steven J Malcolmson
Sep 19, 2020·Organic Letters·Christopher H SchusterSong Chen
Jun 11, 2015·Chemical Reviews·Dong Wang, Didier Astruc
Nov 7, 2019·The Journal of Organic Chemistry·Carlos E Puerto Galvis, Vladimir V Kouznetsov
Jul 19, 2019·The Journal of Organic Chemistry·Mu-Wang ChenYiyuan Peng
Jun 10, 2018·The Journal of Organic Chemistry·Mu-Wang ChenYiyuan Peng
Oct 8, 2021·Organic & Biomolecular Chemistry·Jiabin ShenPengfei Zhang

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