PMID: 15247596Jul 13, 2004Paper

Rubella immunization in human immunodeficiency virus type 1-infected children: cause for concern in vaccination strategies

The Pediatric Infectious Disease Journal
Mylena LimaMaria Isabel De Moraes-Pinto

Abstract

HIV infection can have important although sometimes unexpected consequences, such as contributing to enlargement of the pool of rubella-susceptible children. At the Federal University of São Paulo, Brazil, we assessed response to rubella immunization at 15 months of age in 15 human immunodeficiency virus type 1 (HIV)-infected children, 20 seroreverted children (SR) and 18 healthy control children born to HIV-seronegative mothers (CON). Blood samples were collected before and 3 months after vaccination. All HIV-infected children had started highly active antiretroviral therapy during their first 6 months of life. Serum samples were tested with a rubella IgG enzyme-linked immunosorbent assay kit. HIV children in immunologic categories 2/3 had lower rubella antibody titers (geometric mean, 33 IU/mL) than those from CON (125 IU/mL) and SR group (236 IU/mL) (Tukey, P = 0.01). Antibody values after vaccination were positively associated with CD4 T cell numbers and negatively associated with HIV viral load assessed immediately before vaccination. The percentage of children with protective antibodies after vaccination (above 10.0 IU/mL) was also significantly different among groups (Fisher's exact test, P = 0.013): CON, 94%; SR, 100%; ...Continue Reading

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Citations

Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A F T B GouveaR C M Succi
Nov 16, 2017·The Pediatric Infectious Disease Journal·Regina C M SucciUNKNOWN NISDI Pediatric Study Group 2012
Jun 12, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alessandra ViganòMario Clerici
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Sep 18, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E OnoM I de Moraes-Pinto
Sep 16, 2010·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·Ben TanUNKNOWN approved by NACI.
Mar 10, 2006·Current Infectious Disease Reports·Todd D GleesonSybil A Tasker
Aug 22, 2012·Human Vaccines & Immunotherapeutics·Alberto CagigiPaolo Palma
Apr 25, 2009·Pediatric Research·Sujal GhoshTim Niehues
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Linda AurpibulVirat Sirisanthana
Jun 11, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George K SiberryUNKNOWN Pediatric HIV AIDS Cohort Study PHACS

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