PMID: 47417Jan 25, 1975Paper

Rubella-specific serum and nasopharygeal immunoglobulin responses following naturally acquired and vaccine-induced infection. Prolonged persistence of virus-specific IgM

W Al-NakibJ E Banatvala


Rubella-specific immunoglobulin responses in sera and nasopharyngeal secretions were compared in groups of adult females who had experienced naturally acquired rubella or infection induced by Cendehill, HPV77.DE-5, RA27/3 (subcutaneously and intranasally), and To-336 vaccines. Serum IgG and IgA and nasopharyngeal IgA responses after vaccination by RA27/3 intranasally most closely resembled those induced by naturally acquired infection. However, the other vaccines failed to induce a persistent local IgA response. Levels of local antibody induced by HPV77.DE-5 were especially poor. Virus-specific IgM was detected for prolonged periods. The highest levels and the most persistent response followed vaccination by HPV77.DE-5, four of five volunteers still having rubella-specific IgM at 1 year. Virus-specific IgM persisted for 6 months in seventeen of twenty-five (68%) and for a year in nine of twenty-four (38%) vaccinees. It was still present in four of nine (44%) naturally infected patients at a year.


Jun 1, 1981·Journal of Virological Methods·P N Goldwater, J E Banatvala
Sep 1, 1982·Journal of Virological Methods·O P Lehtonen, O H Meurman
Feb 1, 1984·Journal of Virological Methods·J M BestJ Hodgson
May 24, 1975·Lancet·P L OgraJ K Herd
Apr 1, 1979·The Journal of Hygiene·J E Cradock-WatsonM S Bourne
Aug 1, 1979·The Journal of Hygiene·P HalonenH Bennich
Feb 1, 1976·The Journal of Hygiene·J E Cradock-Watson, M K Ridehalgh
Dec 1, 1989·Epidemiology and Infection·D J MorrisR F Stevens
Oct 1, 1976·British Journal of Clinical Pharmacology·D S Freestone, A L Weinberg
Oct 1, 1977·Annals of the Rheumatic Diseases·T J SchnitzerW C Marshall
Apr 1, 1984·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·J E ParadiseS A Plotkin
Jan 1, 1981·Journal of Medical Virology·A P ColeJ W Harkness
Jan 1, 1980·Journal of Medical Virology·J M BestJ E Banatvala
May 1, 1985·Journal of Medical Virology·E M SalonenA Vaheri
Mar 9, 2007·Clinical and Vaccine Immunology : CVI·C Vauloup-Fellous, L Grangeot-Keros
Oct 5, 2007·Clinical and Vaccine Immunology : CVI·Christelle Vauloup-FellousLiliane Grangeot-Keros
Jul 1, 1979·Journal of Clinical Microbiology·J NikoskelainenD A Stevens
May 1, 1982·Infection and Immunity·P K CoyleL Z Cooper

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.