Rubesanolides C-E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

Organic & Biomolecular Chemistry
Juan ZouHan Dong Sun

Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

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Citations

Dec 25, 2012·Archives of Pharmacal Research·Xu LiuHan Dong Sun
May 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dahong LiJinyi Xu
Jun 25, 2016·Journal of Ethnopharmacology·Ji-Xin LiHong-Jie Zhang
Aug 2, 2017·Natural Product Reports·Miao LiuJian-Xin Pu
Aug 15, 2013·Natural Product Reports·James R Hanson
Jan 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hong DuanKe-Feng Zhai
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kang HeHong-Jie Zhang
Sep 21, 2021·Natural Product Research·Romeo Toko FeunaingRodica Mihaela Dinica

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