Ru@CeO2 yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer

Biomaterials
Xufeng ZhuXiuying Qin

Abstract

Hypoxia is an important factor in forming multidrug resistance, recurrence and metastasis in solid tumors. Nanozymes respond to tumor microenvironment for tumor-specific treatment is a new and effective strategy. In this study, one-pot method was used to synthesize hollow Ru@CeO2 yolk shell nanozymes (Ru@CeO2 YSNs), which possess excellent light-to-heat conversion efficiency and catalytic performance. Antitumor drug ruthenium complex (RBT) and resveratrol (Res) were dual-loaded in Ru@CeO2 YSNs, and a double outer layer structure using polyethylene glycol was constructed to form dual-drug delivery system (Ru@CeO2-RBT/Res-DPEG) that was released on demand. The double outer layer structure increased the biocompatibility of Ru@CeO2 YSNs and effectively prolong the circulation time in blood. Ru@CeO2-RBT/Res-DPEG catalyzes endogenous H2O2 to produce oxygen, which achieve in situ oxygen supply and enhanced dual-chemotherapy and photothermal therapy (PTT) for colorectal cancer. In vitro studies found that Ru@CeO2-RBT/Res-DPEG has good tumor penetration depth and antitumor effect. In addition, Ru@CeO2-RBT/Res-DPEG can alleviate tumor hypoxia, and inhibit metastasis and recurrence of orthotopic and subcutaneous colorectal cancer. Accordi...Continue Reading

Citations

Aug 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lile DongGuobin Hong
Jun 20, 2020·Nanomedicine·Inês MóIlídio J Correia
Dec 17, 2020·Advanced Healthcare Materials·Mengyang ZhaoYongxing Zhao
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuan HuangJinjun Shao
Apr 27, 2021·Nano Today·Jinping WangHongjun Wang
Aug 29, 2021·Pharmaceutics·Kazi Mustafa MahmudMd Asiful Islam

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