Rufinamide efficacy and safety in children aged 1-4 years with Lennox-Gastaut syndrome

Brain & Development
Shin Hye KimHeung Dong Kim

Abstract

The treatment options for Lennox-Gastaut syndrome (LGS), a pediatric epileptic syndrome, are limited, especially in younger children. Rufinamide tablets were safe and effective as an add-on treatment in Korean children and adolescents <20 years of age with LGS. This subgroup analysis aimed to evaluate the efficacy and safety of rufinamide tablets in LGS pediatric patients aged 1-4 years. This was a retrospective, observational study in LGS patients aged 1-4 years who received 12 weeks of treatment with rufinamide orally as an adjuvant treatment between April and June 2010. The proportion of responders (patients with a ≥50% reduction in seizure frequency after rufinamide treatment) was evaluated according to the type of seizure. The proportion of patients who were seizure-free was also evaluated. Adverse events (AEs) were evaluated after 12 weeks of treatment. Among the 15 patients evaluated, one discontinued treatment because of worsening seizures 4 weeks after administration of rufinamide. Seven (46.67%) patients were responders and four patients were seizure-free. There were four responders with convulsive seizures, one each for myoclonic seizures and drop attacks, and spasms. The responder rate was increased to 69.23% by lon...Continue Reading

Citations

Nov 25, 2020·Journal of Child Neurology·Ahmet TanritanirTobias Loddenkemper
Jan 23, 2021·CNS Drugs·Adam Strzelczyk, Susanne Schubert-Bast
Jul 18, 2021·Seizure : the Journal of the British Epilepsy Association·Indar Kumar SharawatLesa Dawman

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