Ru(II)-Catalyzed Regiospecific C-H/O-H Oxidative Annulation to Access Isochromeno[8,1-ab ]phenazines: Far-Red Fluorescence and Live Cancer Cell Imaging

ACS Omega
Sivakalai MayakrishnanParamasivan Thirumalai Perumal

Abstract

A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1-ab]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility.

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Citations

Sep 27, 2018·Chemical Communications : Chem Comm·Sivakalai MayakrishnanParamasivan Thirumalai Perumal
Nov 27, 2020·Chemical Communications : Chem Comm·Sivakalai MayakrishnanNaryanan Uma Maheswari

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Methods Mentioned

BETA
X-ray
NMR
column chromatography
enzyme-linked immunosorbent

Software Mentioned

Gaussian

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