Rules of nonallelic noncomplementation at the synapse in Caenorhabditis elegans.

Genetics
K J YookE M Jorgensen

Abstract

Nonallelic noncomplementation occurs when recessive mutations in two different loci fail to complement one another, in other words, the double heterozygote exhibits a phenotype. We observed that mutations in the genes encoding the physically interacting synaptic proteins UNC-13 and syntaxin/UNC-64 failed to complement one another in the nematode Caenorhabditis elegans. Noncomplementation was not observed between null alleles of these genes and thus this genetic interaction does not occur with a simple decrease in dosage at the two loci. However, noncomplementation was observed if at least one gene encoded a partially functional gene product. Thus, this genetic interaction requires a poisonous gene product to sensitize the genetic background. Nonallelic noncomplementation was not limited to interacting proteins: Although the strongest effects were observed between loci encoding gene products that bind to one another, interactions were also observed between proteins that do not directly interact but are members of the same complex. We also observed noncomplementation between genes that function at distant points in the same pathway, implying that physical interactions are not required for nonallelic noncomplementation. Finally, w...Continue Reading

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Citations

Mar 2, 2002·Traffic·Stephen J Nurrish
Oct 3, 2002·Nature Reviews. Genetics·Jose L Badano, Nicholas Katsanis
Nov 19, 2003·Neuron·Kimberly R SchuskeErik M Jorgensen
Jan 26, 2008·Plant Physiology·R Frank Baker, David M Braun
May 4, 2002·Nature Reviews. Genetics·Erik M Jorgensen, Susan E Mango
Feb 7, 2003·Development·Nicholas J Kaplinsky, Michael Freeling
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Murugesh PadmanarayanaJeremy S Dittman
Feb 13, 2009·Development·Mariam AlexanderPeter John Roy
Jun 23, 2009·The Journal of Pathology·Reiner A Veitia
Aug 12, 2009·Trends in Genetics : TIG·José Manuel Pérez-PérezJosé Luis Micol
Oct 15, 2009·The Journal of Pathology·Reiner A Veitia, James A Birchler
Nov 21, 2009·The New Phytologist·James A Birchler, Reiner A Veitia
Dec 17, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Reiner A Veitia
Jan 20, 2007·Genes & Development·Suzanne Komili, Frederick P Roth

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