Ruminant pestiviruses

The British Veterinary Journal
P F Nettleton, G Entrican

Abstract

The ruminant pestiviruses, bovine virus diarrhoea virus (BVDV) and border disease virus (BDV) are highly successful and important pathogens which infect ruminant species worldwide. Although the serological relationships among ruminant pestiviruses require further clarification, there is growing evidence for two antigenic groups, one of which predominates in cattle and one in sheep. The success of pestiviruses stems from the ability of the non-cytopathic (NCP) biotype of the virus to cross the placenta and establish a persistent infection (PI) in the developing foetus. This biotype should be regarded as the 'normal' biotype with the cytopathic (CP) biotype being an abnormal virus that is usually isolated only from PI animals dying from mucosal disease. Recent molecular evidence points to CP viruses arising from their NCP counterparts by recombination events that include the insertion of host RNA and/or the duplication of viral RNA sequences. However, the biological mechanism through which CP viruses kill cells remains unknown. Virtually all CP and NCP viruses cause only mild, transient clinical symptoms in healthy adult animals and stimulate a protective immune response. Despite the urgent requirement for a safe, effective vacci...Continue Reading

References

Jan 1, 1979·Archives of Virology·H Laude, J Gelfi
May 5, 1979·The Veterinary Record·H A WestburyE Straube
Jul 1, 1992·Comparative Immunology, Microbiology and Infectious Diseases·M S Collett
Jul 1, 1992·Comparative Immunology, Microbiology and Infectious Diseases·P F NettletonJ A Sinclair
Sep 1, 1992·Revue Scientifique Et Technique·K DepnerB Liess
Mar 1, 1992·Clinical and Experimental Immunology·G EntricanP F Nettleton
Apr 1, 1992·Journal of Virological Methods·J S Bootman, P A Kitchin
Jan 1, 1991·Archives of Virology·D V OniskM L Frey
Feb 1, 1991·Journal of Virological Methods·D J PatonG Wensvoort
Jan 26, 1991·The Veterinary Record·D W TarryS Edwards
Jan 1, 1991·Archives of Virology·T L LewisE S Berry
Sep 1, 1991·Veterinary Immunology and Immunopathology·J Jensen, R D Schultz
Sep 1, 1991·The British Veterinary Journal·C Terpstra
Mar 1, 1990·Revue Scientifique Et Technique·P F Nettleton
Mar 1, 1990·Revue Scientifique Et Technique·S R Bolin
Mar 1, 1990·Revue Scientifique Et Technique·C J Howard
Mar 1, 1990·Veterinary Microbiology·P J Durham, L E Hassard
Jul 1, 1990·Australian Veterinary Journal·P D KirklandE Rogan
Aug 1, 1990·Journal of Clinical Microbiology·W XueH C Minocha
Sep 1, 1990·Veterinary Microbiology·K V Brock, L N Potgieter

❮ Previous
Next ❯

Citations

Oct 12, 2001·International Journal for Parasitology·E A InnesD Buxton
Aug 19, 2003·Journal of Comparative Pathology·S W MaleyE A Innes
Oct 24, 2000·Veterinary Microbiology·M D FrayB Charleston
Sep 24, 2002·Veterinary Microbiology·James F Evermann, Julia F Ridpath
May 29, 2003·Biologicals : Journal of the International Association of Biological Standardization·Julia F Ridpath
Dec 17, 2002·Trends in Parasitology·David BuxtonJ P Dubey
Mar 14, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·S VegaR de la Fuente
Feb 18, 1998·Zentralblatt für Veterinärmedizin. Reihe A·J S AgerholmJ F Agger
Jul 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·L Haas
Feb 19, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·T SandvikT Løken
Aug 24, 2010·Journal of Veterinary Internal Medicine·M MudryP Zanolari
Jan 11, 2000·Clinical Microbiology Reviews·P LeyssenJ Neyts
Aug 21, 2010·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·David F TwomeyAlex Schock
Jun 8, 2011·Veterinary Medicine International·Roman M PogranichniyH Leon Thacker
Aug 1, 2007·The Veterinary Quarterly·A T Kalaycioglu
Dec 30, 2015·Trends in Parasitology·Stefano GuidoElisabeth A Innes
Apr 2, 2013·Journal of Virological Methods·Claudia BachofenGeorge C Russell
Jan 22, 2010·Veterinary Parasitology·S AlmeríaL C Gasbarre
Jan 1, 2010·The Veterinary Journal·R Krametter-FroetscherW Baumgartner
Nov 27, 2014·Diagnostic Pathology·Javad JavanbakhtMohammad Hossein Nazemshirazi
Jun 9, 2009·Preventive Veterinary Medicine·S JuliáE L Weber
May 23, 2006·Journal of Comparative Pathology·J P DubeyW Wouda
Oct 11, 2005·Preventive Veterinary Medicine·C BillinisM Sofia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.