Running out of bullets: The challenging management of acute hepatitis and SARS-COV-2 from the SMatteo COvid19 Registry (SMACORE)

Liver International : Official Journal of the International Association for the Study of the Liver
Marta ColaneriRaffaele Bruno

Abstract

Liver impairment is frequent in patients with novel coronavirus disease (COVID-19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are possibly hepatotoxic, the management of patients with COVID-19 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARS-COV-2 infection with respiratory distress as a starting point, we here loop through this condition. Where the available therapeutic options are scarce, we here propose hemoperfusion (HP) as an attractive alternative to both delay any late-stage progression of hyper inflammation process in COVID-19 and remove the toxins involved in acute liver failure.

References

Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 15, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ling XuXin Zheng
Apr 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Hansheng XieHuichang Zhuo

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Citations

Nov 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Elisa MarabottoEdoardo G Giannini
Jun 6, 2021·BMJ Case Reports·Pierre-Clément ThiebaudPierre-Alexis Raynal
Sep 14, 2021·Journal of Zhejiang University. Science. B·Zhifeng ZhouLing Zhang

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