PMID: 25738872Mar 5, 2015Paper

RUNX2 and Osteosarcoma

Anti-cancer Agents in Medicinal Chemistry
Na LiQiping Zheng

Abstract

Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues. RUNX2 is a known essential transcription factor for osteoblast differentiation. RUNX2 has also been linked to many human cancers, including bone cancers and cancer metastasis in bone. However, the view of RUNX2 during OS tumorigenesis has not been unanimous. In this manuscript, we reviewed the osteoblastic origin in OS etiology. The oncogenic property of RUNX2 in human OS studies was briefly summarized. RUNX2 may be involved in OS pathogenesis by regulating cell cycle controlling of (pre)-osteoblasts, which subsequently convert to OS cells. The roles and mechanisms of RUNX2 during OS metastasis and bone metastasis in target cancers (herein prostate and breast cancers), were as described. The potential involvement of Runx2 in multiple mouse OS models that use human OS cell lines (Xenografts), tumor suppressor genes p53 and Rb1 were also discussed. Finally, we updated some microRNAs studies and their...Continue Reading

Citations

Oct 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruyi ZhangQiong Shi
Jan 18, 2016·Veterinary Sciences·Jyotika VarshneySubbaya Subramanian
Oct 19, 2017·Scientific Reports·Yuanlong XieLin Cai
Jan 25, 2019·Scientific Reports·Susan K RatheDavid A Largaespada
Mar 25, 2019·Current Osteoporosis Reports·Eric Hesse, Hanna Taipaleenmäki
Jul 23, 2020·Journal of Cellular Physiology·Emel RothzergJiake Xu
Mar 25, 2021·Cancer Management and Research·Weizhu ZhaoLigang Xing

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