PMID: 22587121May 17, 2012Paper

Rupture of a biomembrane under dynamic surface tension

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
D J Bicout, E Kats

Abstract

How long will a fluid membrane vesicle stressed with a steady ramp of micropipette last before rupture? Or conversely, how high should the surface tension be to rupture such a membrane? To answer these challenging questions we developed a theoretical framework that allows for the description and reproduction of dynamic tension spectroscopy (DTS) observations. The kinetics of the membrane rupture under ramps of surface tension is described as a succession of an initial pore formation followed by the Brownian process of the pore radius crossing the time-dependent energy barrier. We present the formalism and a derive (formal) analytical expression of the survival probability describing the fate of the membrane under DTS conditions. Using numerical simulations for the membrane prepared in an initial state with a given distribution of times for pore nucleation, we study the membrane lifetime (or inverse of rupture rate) and distribution of membrane surface tension at rupture as a function of membrane characteristics like pore nucleation rate, the energy barrier to failure, and tension loading rate. It is found that simulations reproduce the main features of DTS experiments, particularly the pore nucleation and pore-size diffusion-co...Continue Reading

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Citations

Dec 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fang YuanPei Zhong
Apr 27, 2017·Biophysical Journal·Morgan ChabanonPadmini Rangamani

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