Rupture of mitral valve chordae in hypertrophic cardiomyopathy

Archives of Cardiovascular Diseases
Florence BoissierAlbert Hagège

Abstract

While occasional reports of mitral valve chordal rupture have been described in hypertrophic cardiomyopathy, the exact prevalence and characteristics of this event in a large medical cohort have not been reported. To assess the prevalence of mitral valve chordal rupture in hypertrophic cardiomyopathy and the clinical, echocardiographic, surgical and histological profiles of those patients. We searched for patients with mitral valve chordal rupture diagnosed by echocardiography among all electronic files of patients admitted to our centre for hypertrophic cardiomyopathy between 2000 and 2010. Among 580 patients admitted for hypertrophic cardiomyopathy, six patients (1%, 5 men, age 68-71 years) presented with mitral valve chordal rupture, symptomatic in five cases, always involving the posterior mitral leaflet. In all cases, echocardiography before rupture showed mitral valve systolic anterior motion, with anterior (and not posterior) leaflet elongation compared with a random sample of patients with non-obstructive hypertrophic cardiomyopathy (P=0.006) (and similar to that observed in obstructive hypertrophic cardiomyopathy). Significant resting left ventricular outflow tract obstruction was always present before rupture and disa...Continue Reading

References

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Jun 9, 2004·Lancet·Perry Elliott, William J McKenna
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Apr 30, 2008·The Annals of Thoracic Surgery·Ryan K KapleNicholas G Smedira
Oct 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Mathieu GranierAlbert A Hagège

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