Rush specific oral tolerance induction in school-age children with severe egg allergy: one year follow up

Allergology International : Official Journal of the Japanese Society of Allergology
Naoka ItohKazuyuki Kurihara

Abstract

At present, the only treatment for food allergy is to avoid the allergy-causing food. Some trials of specific oral tolerance induction (SOTI) have been carried out, but the rate of tolerance induction was low despite long treatment periods, at least 3 months to several years. A new type of treatment is long desired. The objectives of this study are to perform our rush SOTI for school-age patients with severe egg allergy, and to evaluate the safety and efficacy of this method for one year. Six school-age children (7-12 years of age) with severe IgE-mediated egg allergy confirmed by double-blind, placebo-controlled food challenge (DBPCFC) underwent rush SOTI, in which patients ingested increasing doses of egg several times every day. After rush SOTI, patients ingested the maintenance dose of egg at least twice a week. In DBPCFC, the median threshold dose of egg white inducing allergic reactions was 0.152 g (0.012-0.360 g). All subjects acquired tolerance to more than one whole egg (60 g). It took only 12 days (9-18 days). None experienced any serious reaction. We observed a decrease in IL-10 and an increase in TGF-beta1 at 6 months and a decrease in egg-specific IgE and an increase in egg white-specific IgG4 at 12 months after ru...Continue Reading

References

Aug 1, 1992·The Journal of Allergy and Clinical Immunology·H A Sampson
Aug 1, 1992·The Journal of Allergy and Clinical Immunology·J J OppenheimerD Y Leung
Jan 1, 1997·The Journal of Allergy and Clinical Immunology·A G van HalterenG Kraal
Jun 1, 1997·The Journal of Allergy and Clinical Immunology·H S NelsonD Leung
Jun 9, 1999·The Journal of Allergy and Clinical Immunology·H A Sampson
Aug 12, 1999·The New England Journal of Medicine·S R DurhamK T Nouri-Aria
Sep 15, 1999·Allergy·A BauerP Elsner
Jul 12, 2001·The Journal of Allergy and Clinical Immunology·G KannyF Thevenin
Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S H SichererA Muñoz-Furlong
Aug 10, 2002·The Journal of Allergy and Clinical Immunology·Teresa Boyano-MartínezManuel Martín-Esteban
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·G PatriarcaD Schiavino
Mar 15, 2003·The New England Journal of Medicine·Donald Y M LeungUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Oct 27, 2004·Immunology·Jessica StridStephan Strobel
Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Benjamin L CohenScott H Sicherer
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Mirna Chehade, Lloyd Mayer
Apr 15, 2006·Digestive Diseases and Sciences·Giampiero PatriarcaGiovanni Gasbarrini
Jun 24, 2006·Allergy·B NiggemannK Beyer
Oct 20, 2006·Pediatric Annals·Alessandro Fiocchi, Alberto Martelli
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Ariana D BuchananA Wesley Burks
Feb 24, 2007·The Journal of Allergy and Clinical Immunology·Christophe P FrossardPhilippe A Eigenmann
Mar 16, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naoko TakayamaHiroshi Kiyono
May 19, 2007·Allergy·R AlonsoA Cisteró-Bahíma
Dec 26, 2007·The Journal of Allergy and Clinical Immunology·Giorgio LongoAlessandro Ventura
Mar 11, 2008·The American Journal of Cardiology·Roberta RossiniAntonello Gavazzi

❮ Previous
Next ❯

Citations

Jul 24, 2012·Seminars in Immunopathology·Rima Rachid, Dale T Umetsu
Jan 15, 2013·Current Allergy and Asthma Reports·Linda CoxMark Larche
Jun 9, 2012·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Shindou OkamotoKazunari Kaneko
Jun 15, 2010·Immunotherapy·Toral Kamdar, Paul J Bryce
Jun 7, 2013·Nutrients·Merryn NettingIrmeli Penttila
Feb 28, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Kyoko SudoKazunari Kaneko
Jan 21, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Masaya TakahashiKazunari Kaneko
May 3, 2014·The Journal of Clinical Investigation·Corinne A Keet, Robert A Wood
Jun 26, 2014·Pediatric Allergy, Immunology, and Pulmonology·Giovanni B PajnoGiuseppe Crisafulli
Dec 15, 2010·European Journal of Pediatrics·Zsolt SzépfalusiEleonora Dehlink
Aug 21, 2015·Expert Review of Clinical Pharmacology·Aaron K KobernickA Wesley Burks
Jul 7, 2015·Expert Review of Gastroenterology & Hepatology·Allison J Burbank, Wesley Burks
Apr 9, 2014·Expert Review of Clinical Immunology·Andrea D PraticòSalvatore Leonardi
Jan 15, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sugimoto MayumiKido Hiroshi
Jul 28, 2012·Allergologia et immunopathologia·V Fuentes-AparicioE Alonso-Lebrero
May 23, 2012·The Journal of Allergy and Clinical Immunology·Matthew C TunisJean S Marshall
Aug 2, 2011·Allergologia et immunopathologia·E BarbiA Ventura
May 3, 2011·Immunology and Allergy Clinics of North America·Michael H LandA Wesley Burks
Dec 7, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brian P VickeryA Wesley Burks
Dec 8, 2015·Journal of Nutritional Science and Vitaminology·Akihiro MaetaKyoko Takahashi
Dec 1, 2015·Immunology and Allergy Clinics of North America·Allison J BurbankRobert A Wood
Aug 14, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paolo MeglioElena Galli
Apr 5, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R García RodríguezF Guerra
Sep 11, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Iride Dello IaconoStefano Miceli Sopo
Apr 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carmelo EscuderoMaría Dolores Ibáñez
Aug 3, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M L K Tang, D J Martino
May 21, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Leticia VilaMaria L Sanz
Jun 24, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Asako NozawaKazuyunki Kurihara
Dec 21, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Vazquez-OrtizA M Plaza
Aug 4, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C EscuderoM D Ibáñez
Sep 1, 2015·The Journal of Allergy and Clinical Immunology·Sakura SatoMotohiro Ebisawa
Apr 10, 2016·The Journal of Allergy and Clinical Immunology·Robert A Wood
Mar 1, 2016·Current Allergy and Asthma Reports·Christina S K Yee, Rima Rachid
May 4, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura PerezábadIván López-Expósito
Jan 23, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Kazuyuki Kurihara
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Philippe BeginKari C Nadeau
Feb 26, 2015·Immunotherapy·Andrea D Praticò, Salvatore Leonardi
Jul 17, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Carmen M Cabrera, José M Urra
Oct 26, 2016·The World Allergy Organization Journal·Yu OkadaMotohiro Ebisawa
Sep 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Aaron K Kobernick, A Wesley Burks
Jan 18, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Janice M Joneja
Jan 15, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Inmaculada Pérez-RangelMaría Dolores Ibáñez
Dec 4, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Masayuki AkashiYukihiro Ohya
Jul 12, 2017·Human Vaccines & Immunotherapeutics·François GrahamPhilippe Bégin
Apr 21, 2018·The Cochrane Database of Systematic Reviews·Olga RomantsikMaria Grazia Calevo
Nov 19, 2014·The Cochrane Database of Systematic Reviews·Olga RomantsikMaria Grazia Calevo
Sep 6, 2018·Human Vaccines & Immunotherapeutics·Manish Ramesh, Merhunisa Karagic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
Ariana D BuchananA Wesley Burks
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R García RodríguezF Guerra
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
P MeglioElena Galli
© 2022 Meta ULC. All rights reserved