Russell bodies in a skin biopsy: a case report.

Journal of Medical Case Reports
Joanne VerheijLawrence Rozendaal

Abstract

The presence of eosinophilic bodies in a skin biopsy can be found in a variety of situations and this may present a challenge to the pathologist. The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies. During a routine examination of a skin biopsy with actinic keratosis taken from the cheek of a 61-year-old man, clusters of eosinophilic bodies were seen within an inflammatory infiltrate in the dermis, both intracytoplasmic and extracellular. Using additional immunohistochemical staining, these structures were identified as polyclonal Russell bodies. The differential diagnosis of intracytoplasmic eosinophilic structures in a skin biopsy includes Russell bodies, an uncommon finding that may be associated with chronic inflammatory conditions.

References

Aug 1, 1989·Journal of Cutaneous Pathology·S Aiba, H Tagami
Apr 1, 1986·The American Journal of Dermatopathology·J W Patterson
Aug 9, 2002·Pathology International·Shin-Ichiro KitajiriSusumu Ikehara
Jul 24, 2004·Archives of Pathology & Laboratory Medicine·Andreas ErbersdoblerGuntram Lock
Mar 4, 2005·Virchows Archiv : an International Journal of Pathology·Arzu EnsariRamazan Idilman
Mar 16, 2006·Journal of Clinical Pathology·C J R Stewart, D V Spagnolo
May 17, 2006·International Journal of Surgical Pathology·Ricardo Drut, Alejandro B Olenchuk
Dec 5, 2006·Journal of Clinical Pathology·S PaikY C Lee

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Citations

Oct 12, 2018·International Journal of Surgical Pathology·Paulina HenryLouis Libbrecht
Sep 16, 2020·Ear, Nose, & Throat Journal·Chuan-Jen HungYaoh-Shiang Lin
Sep 20, 2019·Clinical Case Reports·Maryna A VazmitselRichard D Hammer
Nov 7, 2020·The American Journal of Dermatopathology·Biswanath BeheraNachiappa Ganesh Rajesh

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Methods Mentioned

BETA
biopsy

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