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Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis

Free Radical Biology & Medicine

Dec 25, 2019

Youbo ZhangFrank J Gonzalez

Abstract

Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of Evodia rutaecarpa, was reported to suppress IBD. However, the mechanism by which RUT ameliorates dextran sulfate sod...read more

Mentioned in this Paper

Intestines
Docking -molecular Interaction
Laboratory mice
Kelch Domain
Epithelial Cells
Intestinal Diseases
KEAP1
Extracellular
NF-E2-Related Factor 2
Study
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Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis

Free Radical Biology & Medicine

Dec 25, 2019

Youbo ZhangFrank J Gonzalez

PMID: 31874248

DOI: 10.1016/j.freeradbiomed.2019.12.012

Abstract

Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of Evodia rutaecarpa, was reported to suppress IBD. However, the mechanism by which RUT ameliorates dextran sulfate sod...read more

Mentioned in this Paper

Intestines
Docking -molecular Interaction
Laboratory mice
Kelch Domain
Epithelial Cells
Intestinal Diseases
KEAP1
Extracellular
NF-E2-Related Factor 2
Study

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PARP Inhibitors

PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.

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The American Journal of Chinese MedicineSeptember 10, 2011
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Paper Details
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