Ruthenium-based complex nanocarriers for cancer therapy

Biomaterials
Gaetano MangiapiaLuigi Paduano

Abstract

A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.

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Citations

Feb 21, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Luigi Messori, Antonello Merlino
Jun 20, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Francesca CuomoFrancesco Lopez
Feb 2, 2016·Biomacromolecules·Alfredo Maria GravagnuoloPaola Giardina
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Jul 15, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Domenica MusumeciDaniela Montesarchio
May 4, 2015·Journal of Colloid and Interface Science·Nino RuoccoLuigi Paduano
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Sep 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Claudia RiccardiDaniela Montesarchio
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Jan 8, 2018·ACS Biomaterials Science & Engineering·Claudia RiccardiDaniela Montesarchio
Jan 8, 2019·Inorganic Chemistry·Marco CaterinoAlessandro Vergara

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