Ruthenium-Catalyzed Cascade Annulation of Indole with Propargyl Alcohols

Angewandte Chemie
Julia KaufmannEdgar Haak

Abstract

Cascade transformations forming multiple bonds and one-pot procedures provide rapid access to natural-product-like scaffolds from simple precursors. These atom-economic processes are valuable tools in organic synthesis and drug discovery. Herein, we report on ruthenium-catalyzed cascade annulations of indole with readily available propargyl alcohols. These provide rapid access to diverse carbazoles, cyclohepta[b]indoles, and further fused polycycles with high selectivity. A bifunctional ruthenium complex featuring a redox-coupled cyclopentadienone ligand acts as a common catalyst for the different cascade processes.

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Citations

Apr 10, 2019·Organic & Biomolecular Chemistry·Andrey G LvovValerii Z Shirinian
May 29, 2020·Chemistry : a European Journal·Dina Christina TymannMartin Hiersemann
Jul 22, 2021·Organic & Biomolecular Chemistry·Jonali Das, Sajal Kumar Das

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