Ruthenium-catalyzed remote C5-sulfonation of N-alkyl-8-aminoquinolines

Organic & Biomolecular Chemistry
Xuri LiuBo Wang

Abstract

There is an increasing demand for the methodologies of positionally selective remote C-H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.

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Citations

Dec 5, 2019·Organic & Biomolecular Chemistry·Chandrashekar Mudithanapelli, Mi-Hyun Kim
Jun 12, 2020·Topics in Current Chemistry·Zhihui XuRenhua Qiu

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Methods Mentioned

BETA
column chromatography

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