Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

Dalton Transactions : an International Journal of Inorganic Chemistry
Lai-Hon ChungChun-Yuen Wong

Abstract

The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

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Citations

May 1, 2019·Chemistry : a European Journal·Chi-Fung YeungChun-Yuen Wong
Jan 17, 2020·Chemistry : a European Journal·Lai-Hon ChungChun-Yuen Wong
May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sze-Wing NgChun-Yuen Wong
Oct 20, 2020·Chemical Reviews·Dafa ChenHaiping Xia

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