Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin

British Journal of Pharmacology
T L BuckleyT J Williams

Abstract

It has been suggested that ruthenium red has a selective inhibitory effect on capsaicin-induced nociceptor stimulation. We have investigated the effect of ruthenium red on oedema formation and vasodilatation induced by intradermal (i.d.) injection of capsaicin in the rabbit in vivo. Responses induced by capsaicin were inhibited by ruthenium red, but responses induced by bradykinin, N-formyl-methionyl-leucyl-phenylalanine (FMLP), platelet activating factor (PAF), histamine and calcitonin gene-related peptide (CGRP) were not affected. These results suggest that ruthenium red selectively inhibits capsaicin-induced local plasma protein leakage and vasodilatation in the rabbit skin microvasculature.

References

Mar 1, 1979·British Journal of Pharmacology·T J Williams
Jun 1, 1987·Neuroscience·R HåkansonF Sundler
Feb 28, 1989·European Journal of Pharmacology·R Amann, F Lembeck
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 3, 1985·Nature·S D BrainI MacIntyre

❮ Previous
Next ❯

Citations

May 1, 1990·Trends in Pharmacological Sciences·P J BarnesD F Rogers
May 31, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jia-You FangYi-Hung Tsai
Jun 1, 1991·British Journal of Pharmacology·P Ellis, E Müller-Schweinitzer
Jun 1, 1992·British Journal of Pharmacology·I D ChapmanJ Morley
Nov 1, 1993·British Journal of Pharmacology·Z Y Wang, R Håkanson
Feb 1, 1995·British Journal of Pharmacology·P Newbold, S D Brain
Nov 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Jan 6, 2004·Medicinal Research Reviews·Raimund Mannhold
Sep 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen D RobinsonKairbaan M Hodivala-Dilke
May 12, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·E Müller-SchweinitzerW E Haefeli
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Michael D SouthallJeffrey B Travers
Jun 30, 1992·Annals of the New York Academy of Sciences·S D BrainP Wilsoncroft
Nov 7, 1998·Life Sciences·K SenoF W Leung
Dec 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J FretlandT S Gaginella
Jan 1, 1991·Pulmonary Pharmacology·J N Baraniuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.