Ruthenium(II)-Catalyzed Positional Selective C-H Oxygenation of N-Aryl-2-pyrimidines

The Journal of Organic Chemistry
Tanumay SarkarTharmalingam Punniyamurthy

Abstract

Efficient Ru-catalyzed regioselective C-H oxygenation of N-aryl-2-pyrimidines is described with aryl carboxylic acids in the presence of AgSbF6 as an additive and Ag2CO3 as an oxidant. The reaction can be extended to alkyl, heteroaryl, and α,β-unsaturated carboxylic acids. The regioselectivity, broad substrate scope, and functional group tolerance are the significant practical advantages.

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Citations

Aug 2, 2019·Organic & Biomolecular Chemistry·Yu-Chao YuanRafael Gramage-Doria
Aug 3, 2018·Organic & Biomolecular Chemistry·Pinaki Bhusan DeTharmalingam Punniyamurthy
Feb 1, 2019·Organic & Biomolecular Chemistry·Kangkan TalukdarTharmalingam Punniyamurthy
Dec 14, 2018·Chemical Communications : Chem Comm·Tariq A ShahTharmalingam Punniyamurthy
Jul 1, 2020·Chemistry : a European Journal·Qingqing BuLutz Ackermann
Jun 25, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tanumay SarkarTharmalingam Punniyamurthy
Jan 11, 2019·The Journal of Organic Chemistry·Yu-Chao YuanRafael Gramage-Doria

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