Ruthenium(II) Polypyridyl Complexes as Photosensitizers for Antibacterial Photodynamic Therapy: A Structure-Activity Study on Clinical Bacterial Strains

ChemMedChem
Tony Le GallTristan Montier

Abstract

As a growing public health concern, the worldwide spread of antimicrobial resistance urges the development of new therapies. Antibacterial photodynamic therapy (a-PDT) may be an alternative to conventional antibiotic therapy. Herein we report the synthesis and characterization of seven original reactive oxygen species (ROS)-producing ruthenium(II) polypyridyl complexes. These are part of a collection of 17 derivatives varying in terms of the nature of the substituent(s), molecular symmetry, electrical charge, and counterions. They were characterized by considering 1) their physical properties (absorption coefficient at irradiation wavelength, 1 O2 generation quantum yield, luminescence) and 2) their antibacterial activity in a series of photodynamic assays using Gram-positive and Gram-negative bacteria of clinical relevance. The results unveiled some structure-activity relationships: one derivative that combines multiple beneficial features for a-PDT was effective against all the bacteria considered, regardless of their Gram status, species, or antibiotic resistance profile. This systematic study could guide the design of next-generation ruthenium-based complexes for enhanced antibacterial photodynamic strategies.

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Citations

Aug 23, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bingqing LiuWenfang Sun
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiangjun LiuShaoqi Tian
Jun 18, 2020·Antibiotics·Adelaide AlmeidaMaria G P M S Neves
Jun 27, 2019·Advanced Healthcare Materials·Qingyan JiaWei Huang
Feb 5, 2021·The Journal of Physical Chemistry. B·Aoibhín A CullenMary T Pryce
Apr 22, 2021·Photochemistry and Photobiology·Avijita JainZachary P Malone
Jul 3, 2021·Pharmaceutics·Alexandra-Cristina Munteanu, Valentina Uivarosi
Apr 16, 2019·Bioconjugate Chemistry·Ying XiongHui-Wang Ai
Nov 17, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nidia Maldonado-CarmonaStéphanie Leroy-Lhez

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