Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Darren GriffithCeline J Marmion

Abstract

Reaction of 3-pyridinehydroxamic acid and 4-pyridinehydroxamic acid (3-pyha and 4-pyha) with either [NBu4][RuCl4(dmso-S)2] or [(dmso)2H][RuCl4(dmso-S)2] (dmso is dimethyl sulfoxide) in acetone afforded three new ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes: [NBu4][trans-RuCl4(dmso-S)(4-pyha)] x CH3CO CH3 (1), [3-pyhaH][trans-RuCl4(dmso-S)(3-pyha)] (2) and [4-pyhaH][trans-RuCl4(dmso-S)(4-pyha)] (3). The solid-state structure of [NBu4][trans-RuCl4(dmso-S)(4-pyha)] x CH3COCH3 (1) was determined by X-ray crystallography. 2 and 3 were pharmacologically evaluated for their in vitro cytotoxicity, their ability to inhibit cell invasion and their gelatinase activity. 2 and 3 were devoid of cytotoxicity against the cell lines tested. 2 inhibited invasion of the highly invasive MDA-MB-231 cells to a much greater extent than 3. Contrary to expectations, neither 2 nor 3 had any inhibitory effect on matrix metalloproteinase (MMP) production and/or activity and in fact 3 was found to enhance the production and/or activity of both MMP-2 and MMP-9.

References

Nov 28, 2000·Expert Opinion on Investigational Drugs·W P Steward, A L Thomas
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SavaG Mestroni
Aug 13, 2002·Current Medicinal Chemistry·E M F MuriJ S Williamson
Apr 18, 2003·Journal of Medicinal Chemistry·Anna C G HotzeJan Reedijk
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Dec 8, 2004·Current Topics in Medicinal Chemistry·Enzo AlessioGianni Sava
Feb 23, 2005·Current Medicinal Chemistry·C A KontogiorgisD J Hadjipavlou-Litina
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Charles J Malemud
Dec 24, 2005·International Journal of Clinical Pharmacology and Therapeutics·M A JakupecB K Keppler
Jan 3, 2006·European Journal of Pharmacology·Ahmad ShariftabriziMohammad Reza Khorramizadeh
Apr 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul J Dyson, Gianni Sava
Apr 14, 2006·Current Medicinal Chemistry·Irena Kostova
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
May 23, 2006·Current Medicinal Chemistry·Adnan Salim Abu-Surrah, Mika Kettunen
Jun 23, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Viktor Brabec, Olga Nováková
Sep 1, 2006·Journal of Medicinal Chemistry·Carsten A VockPaul J Dyson
Dec 16, 2006·Chemistry : a European Journal·Timothy W FailesTrevor W Hambley
Jan 2, 2007·Journal of Inorganic Biochemistry·Timothy W Failes, Trevor W Hambley
Feb 23, 2007·Archiv der Pharmazie·Ingo Ott, Ronald Gust
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland

❮ Previous
Next ❯

Citations

Jun 25, 2013·Journal of Industrial Microbiology & Biotechnology·Shilpi AgarwalBijan Choudhury
Jul 16, 2010·Bioinorganic Chemistry and Applications·Jakob KljunIztok Turel
Feb 2, 2010·Journal of Inorganic Biochemistry·Camilla C GolfetoAlzir A Batista

❮ Previous
Next ❯