Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NFκB/MAPK pathway

Chemico-biological Interactions
Sana NafeesSarwat Sultana

Abstract

Cyclophosphamide is a potent anticancer agent. However its clinical use is restricted because of its marked organ toxicity associated with increased oxidative stress and inflammation. The present study was designed to demonstrate the protective effects of rutin, a naturally occurring bioflavonoid against the hepatotoxicity induced by CP. Rats were subjected to oral pretreatment of rutin (50 and 100 mg/kg b wt) against hepatotoxicity induced by i.p. injection of CP (150 mg/kg b wt) and were sacrificed after 24 h. Hepatoprotective effects of rutin were associated with upregulation of antioxidant enzyme activities and down regulation of serum toxicity markers. Rutin was able to down regulate the levels of inflammatory markers like TNF-α, IL-6 and expressions of p38-MAPK, NFκB, i-NOS and COX-2. Histopathological changes further confirmed the biochemical and immunohistochemical results showing that CP caused significant structural damage to liver which were reversed by pretreatment of rutin. Therefore, our study revealed that rutin may be a promising modulator in attenuating CP induced oxidative stress, inflammation and hepatotoxicity via targeting NFκB and MAPK pathway.

References

Feb 1, 1981·Archives of Biochemistry and Biophysics·J R WrightP R Miles
Jun 1, 1995·Mutation Research·R H Liu, J H Hotchkiss
Aug 1, 1993·Free Radical Biology & Medicine·J D Adams, L K Klaidman
Jun 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E GiladC Szabó
Sep 28, 1999·Molecular Medicine Today·E Herlaar, Z Brown
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Oct 6, 2000·Journal of Pain and Symptom Management·R J Dunlop, C W Campbell
Nov 6, 2001·The Journal of Biological Chemistry·Qiang Ma, Krista Kinneer
May 17, 2002·The Journal of Nutritional Biochemistry·N Soorappan RajasekaranS Niranjali Devaraj
Sep 3, 2003·Nature Reviews. Drug Discovery·Sanjay KumarJohn C Lee
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K B H Kumar, R Kuttan
Jul 14, 2005·Molecular and Cellular Biochemistry·Elangovan SelvakumarPalaninathan Varalakshmi
Sep 10, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Subramanian SenthilkumarMunismay Suresh Babu
Apr 6, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Riánsares ArriazuLuis Santamaría
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Jul 11, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K BhatiaS Raisuddin
Mar 28, 2008·Cancer Letters·Mario E Goetz, Andreas Luch
Sep 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kanchan BhatiaSheikh Raisuddin
Oct 18, 2008·Nature Reviews. Immunology·Sankar Ghosh, Matthew S Hayden
Jul 28, 2009·Brain Research·Mohd Moshahid KhanFakhrul Islam
Oct 28, 2009·Nature Reviews. Immunology·Ruslan Medzhitov, Tiffany Horng
Feb 4, 2010·Acta Cirúrgica Brasileira·Anna Carolina Batista DantasAldo Cunha Medeiros
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina UivarosiDana Marinescu
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Feb 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Tom Luedde, Robert F Schwabe
May 25, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wani ArjumandSarwat Sultana
Nov 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sung-Hwan KimJong-Choon Kim

❮ Previous
Next ❯

Citations

Jun 17, 2016·Environmental Toxicology and Pharmacology·Amr A FouadWalid N Al-Melhim
Dec 10, 2015·Acta Cirúrgica Brasileira·Esra ErdoganEmin Oztas
Mar 13, 2017·Bioorganic & Medicinal Chemistry Letters·Lan LiMing Ye
Oct 15, 2018·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
Dec 14, 2018·International Journal of Molecular Sciences·Valéria Costa da SilvaGerlane Coelho Bernardo Guerra
Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Jayant PatwaGopabandhu Jena
Oct 1, 2020·Pharmacology Research & Perspectives·Mohamed El-ShabrawyHanaa Wanas
Jul 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mak-Soon LeeYangha Kim
May 24, 2020·Antioxidants·Taylor McElroy, Antiño R Allen
Apr 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yadi WangLiqun Ren
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Muluken Altaye AyzaAbera Hadgu Berhe
May 27, 2020·Oxidative Medicine and Cellular Longevity·Muluken Altaye AyzaAbera Hadgu Berhe
Apr 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John F Lechner, Gary D Stoner
Dec 10, 2020·Phytotherapy Research : PTR·Amir ImaniSolmaz Maleki Dizaj
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak
Nov 19, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yong-Qiang LiuYong-Xian Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Summya RashidSarwat Sultana
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Wani ArjumandSarwat Sultana
© 2022 Meta ULC. All rights reserved