Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Daniela D Almeida PeresAndré Rolim Baby

Abstract

Ultraviolet (UV) radiation is responsible for sunburns, skin cancer, photoaging, and the production of reactive oxygen species (ROS). The awareness on preventing these deleterious effects made the use of anti-UVB formulations an important part of population habits; however, despite the availability of several antioxidants capable of ROS scavenging, the pharmaceutical market lacks products associating UV filters with natural compounds of proven efficacy. Here, we investigated the effect of rutin, a flavonoid with antioxidant activity, associated with UVB filters in dermocosmetic preparations. Formulations were assessed through its antioxidant activity, in vitro photoprotective effectiveness, photostability, and in vivo skin tolerance (hydration, transepidermal water loss, and erythema). Samples containing rutin were compatible with the human skin and presented a pronounced antioxidant potential, with scavenging activity values 75% higher than the ones containing only UVB filters. Although rutin could not prevent the sunscreens photodegradation post-irradiation, the bioactive compound significantly increased the formulations critical wavelengths, showing a photoprotective gain, especially in the UVA range. In conclusion, the abso...Continue Reading

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Jul 30, 2008·International Journal of Pharmaceutics·Maria Valéria Robles VelascoAndré Rolim Baby
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Citations

May 10, 2020·Journal of Cosmetic Dermatology·Fernanda D SarrufAndré R Baby
May 28, 2019·Frontiers in Physiology·Catarina RosadoAndré Rolim Baby
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ramya VijayakumarMohd Razak Hamdan
Dec 10, 2020·Phytotherapy Research : PTR·Amir ImaniSolmaz Maleki Dizaj
Mar 2, 2021·Colloids and Surfaces. B, Biointerfaces·Renata Miliani MartinezAndré Rolim Baby
Oct 16, 2020·Phytotherapy Research : PTR·Ramin NegahdariSafa Raeesi

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