RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer

Frontiers in Endocrinology
Thatchawan ThanasupawatThomas Klonisch

Abstract

The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

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Citations

Jun 28, 2018·Molecular Oncology·Thatchawan ThanasupawatThomas Klonisch
Nov 16, 2018·International Journal of Molecular Medicine·Hai-Xia QuXiang-Jun Jiang

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Methods Mentioned

BETA
xenograft
xenografts
PCR
glycosylation
co-immunoprecipitation

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