Ryanodine-mediated conversion of STP to LTP is lacking in synaptopodin-deficient mice

Brain Structure & Function
Gayane Grigoryan, M Segal

Abstract

In previous studies we and others have found that activation of ryanodine receptors (RyRs) facilitate expression of long-term potentiation (LTP) of reactivity to afferent stimulation in hippocampal slices, with a more pronounced action in the ventral hippocampus. We have also been able to link the involvement of synaptopodin (SP), an actin-binding protein, with neuronal plasticity via its interaction with RyRs. To test this link more directly, we have now compared the ability of ryanodine to convert short-term to LTP in hippocampal slices taken from normal and SP-knockout (SPKO) mice. Indeed, SPKO hippocampus expresses lower concentrations of RyRs and in slices of these mice ryanodine is unable to facilitate conversion of short-term to LTP. These observations link functionally SP with calcium stores.

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Citations

Sep 24, 2016·Biochemical and Biophysical Research Communications·Clark A BriggsGrace E Stutzmann
Jul 18, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Zahid PadamseyNigel J Emptage
May 28, 2016·Neuromolecular Medicine·Ronald S PetraliaPamela J Yao
Feb 14, 2021·Scientific Reports·Raul Loera-ValenciaPaula Merino-Serrais
Aug 20, 2021·IBRO Neuroscience Reports·Athina MiliouCostas Papatheodoropoulos

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