Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease

The International Journal of Biochemistry & Cell Biology
Amanda DennissNicole A Beard

Abstract

Calcium release from internal stores is a quintessential event in excitation-contraction coupling in cardiac and skeletal muscle. The ryanodine receptor Ca2+ release channel is embedded in the internal sarcoplasmic reticulum Ca2+ store, which releases Ca2+ into the cytoplasm, enabling contraction. Ryanodine receptors form the hub of a macromolecular complex extending from the extracellular space to the sarcoplasmic reticulum lumen. Ryanodine receptor activity is influenced by the integrated effects of associated co-proteins, ions, and post-translational phosphor and redox modifications. In healthy muscle, ryanodine receptors are phosphorylated and redox modified to basal levels, to support cellular function. A pathological increase in the degree of both post-translational modifications disturbs intracellular Ca2+ signalling, and is implicated in various cardiac and skeletal disorders. This review summarises our current understanding of the mechanisms linking ryanodine receptor post-translational modification to heart failure and skeletal myopathy and highlights the challenges and controversies within the field.

Citations

Apr 28, 2019·Journal of Cell Science·Samantha C SalvageAngela F Dulhunty
Jul 2, 2020·British Journal of Pharmacology·Ana Carolina Moreira SouzaSylvain Richard
Aug 26, 2020·Diabetologia·Francisco Jaque-FernandezVincent Jacquemond
Feb 26, 2020·Current Alzheimer Research·Mounia Chami, Frédéric Checler
Sep 22, 2020·Circulation·Daniel J Blackwell, Björn C Knollmann
Jul 23, 2020·Biophysics Reviews·Amanda L DennissNicole A Beard
Sep 4, 2020·The Journal of Biological Chemistry·Wenting GuoS R Wayne Chen
May 22, 2021·Ecotoxicology and Environmental Safety·Zhijuan HuangChaoliang Lei

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