Rye flour induces a stronger early bronchial response than wheat flour in occupational asthma

Allergy
L BensefaD Choudat

Abstract

Our aims were to compare the doses of wheat and rye flour that induce early bronchial responses in occupationally exposed asthmatic subjects and to assess the effects of the dose of inhaled flour, the duration of exposure and the dose rate. Ten patients underwent tests with lactose, wheat flour and rye flour. We compared the decrease in forced expiratory volume in 1 s (FEV(1)) observed during the challenge with flour and with lactose. We also calculated the amount of flour that was instantaneously active. Seven subjects had significantly decreased FEV(1) values following exposure to wheat and rye flour and two subjects only did so for rye flour. The provocative dose (PD, dose required to reduce FEV(1) by 15%) of rye was lower than that of wheat flour (geometric mean; PD(15) rye: 95 microg; wheat: 368 microg). The calculated doses of rye and wheat flour were better correlated with the change in FEV(1) than were the cumulative doses. The bronchial response was greater with rye than with wheat flour. The response was related to the dose of allergen inhaled and to the dose rate.

References

Apr 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C P SandifordA J Newman-Taylor
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
May 1, 1993·The American Review of Respiratory Disease·O VandenplasJ L Malo
Aug 1, 1997·Occupational Medicine·H Savolainen
Aug 18, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J F FabrièsF Conso
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K PalosuoT Reunala
Mar 1, 1993·The European Respiratory Journal·P J SterkJ L Malo

❮ Previous
Next ❯

Citations

Sep 1, 2000·International Journal of Pediatric Otorhinolaryngology·G Taborelli Calevo
May 22, 1998·International Journal of Pediatric Otorhinolaryngology·A GolzS Parush
Oct 22, 2008·The Annals of Occupational Hygiene·Michel LaurièreDominique Choudat
Mar 5, 2010·The Annals of Occupational Hygiene·Roslynn BaatjiesMohamed Jeebhay
Jul 21, 2005·American Journal of Industrial Medicine·Rodney Ehrlich, Ruth Prescott
Feb 28, 2008·American Journal of Industrial Medicine·Antonio LetránSantiago Quirce
Oct 31, 2012·Molecular Nutrition & Food Research·Hamza MameriJean-Charles Gaudin
Jul 18, 2015·Journal of Agricultural and Food Chemistry·Hamza MameriSandra Denery-Papini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Industrial Medicine
Rodney Ehrlich, Ruth Prescott
Clinical Otolaryngology and Allied Sciences
A W Blayney, B H Colman
Archives of Otolaryngology--head & Neck Surgery
C M Bower, R T Cotton
Emergency Medicine Clinics of North America
Kevin A Kerber
© 2022 Meta ULC. All rights reserved