RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure

Journal of Cardiovascular Electrophysiology
Pietro FranciaMassimo Volpe

Abstract

Cardiac ryanodine receptor 2 (RyR2) is critical to the electrical homeostasis of cardiomyocytes. Its gene variant rs3766871 entails channel destabilization and enhanced intracellular Ca(2+) oscillation, thus promoting cardiac arrhythmias. We investigated whether the RyR2 rs3766871 variant is associated with aborted sudden cardiac death or ICD therapy for ventricular tachycardia (VT)/fibrillation (VF) in heart failure (HF) patients implanted with a cardioverter defibrillator (ICD). A total of 183 HF patients with primary or secondary prevention ICD were divided in 2 groups. A VT/VF group was composed of secondary prevention patients and primary prevention patients with appropriate ICD intervention for VT/VF. An ICD control group was composed of primary prevention patients free from any appropriate ICD intervention after 43 ± 25 months follow-up. Study subjects were genotyped with respect to the rs3766871 RyR2 gene variant. Hazard ratios (HRs) were derived from Cox proportional-hazards regression analysis. In all, 56 patients constituted the VT/VF group and 127 patients the ICD control group. Male sex (HR: 3.02; 95% CI: 0.99-9.18; P = 0.05), atrial fibrillation (AF; HR: 2.33; 95% CI: 0.89-6.10; P = 0.08), and underuse of β-blocke...Continue Reading

References

Jun 1, 1996·Nature Structural Biology·E V OrlovaW Chiu
Oct 8, 1999·Biophysical Journal·I I SeryshevaS L Hamilton
Sep 1, 2004·Biochemical and Biophysical Research Communications·Mark Scoote, Alan J Williams
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·Maninder S BediBarry London
Dec 16, 2005·Current Opinion in Cardiology·Michael H Gollob
Apr 26, 2008·Heart Failure Reviews·Dawood Darbar
Jun 9, 2009·Journal of Cardiovascular Electrophysiology·Pietro FranciaRiccardo Cappato
Feb 27, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Diego ChemelloNadine Clausell
Sep 21, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pietro FranciaMassimo Volpe

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Citations

Jun 18, 2021·World Journal of Stem Cells·Steven B KarchMassimo Volpe

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