S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity

Journal of Neuroimmunology
A KlegerisPatrick L McGeer

Abstract

The protective effects of non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease have been demonstrated in multiple epidemiological studies. It has been hypothesized that this is due to their effects on amyloid beta-peptide (Abeta) metabolism, which is independent of the NSAID stereoisoform, rather than inhibition of cyclooxygenase (COX), which is a property of S-enantiomers. We compared the neuroprotective activity of S- and R-enantiomers of flurbiprofen and ibuprofen in a standard assay where secretions from activated human THP-1 or microglial cells are toxic to neuroblastoma SH-SY5Y cells. We found S- but not R-enantiomers to be protective at low concentrations, which is consistent with a COX-dependent mechanism.

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Citations

Sep 21, 2013·Acta Neuropathologica·Patrick L McGeer, Edith G McGeer
Jun 30, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·J A López-VillodresJ A González-Correa
Apr 27, 2005·Brain Research. Brain Research Reviews·Laura GaspariniDavid Morgan
Jul 12, 2017·Journal of Child and Adolescent Psychopharmacology·Ellen J SpartzJennifer Frankovich
Aug 9, 2005·The Journal of Biological Chemistry·Andrew CordleGary Landreth

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