PMID: 9451493Feb 6, 1998Paper

S-(+)-ketamine. Circulatory interactions during total intravenous anesthesia and analgesia-sedation

Der Anaesthesist
H A Adams

Abstract

General cardiovascular properties of ketamine: "In vitro", ketamine has moderate negative inotropic effects. "In vivo", a significant central sympathomimetic action with consecutive hemodynamic effects is dominant. The sympathomimetic potency of ketamine is one of the most significant pharmacological features of the substance with direct clinical implications. Monoanaesthesia with S-(+)-ketamine: After application of racemic ketamine or S(+)-ketamine as well, identic and significant increases in plasma catecholamines, arterial pressure and heart rate are observed. This outstanding sympathomimetic action is beneficial in induction of patients with shock or asthmatic state. TIVA and analgosedation with S-(+)-ketamine and midazolam: The sympathomimetic effect of S(+)-ketamine, and racemic ketamine as well, is mitigated by midazolam. Nevertheless, significant increases in heart rate and arteriel pressure might be observed. Clinical use of the combination is common in short procedures like reposition maneuvers. Of greater importance is the use for analgosedation in patients with cardiovascular instability, particularly in patients with exogenous catecholamine demand. TIVA and analgosedation with S-(+)-ketamine and propofol: When S(+...Continue Reading

Citations

Jul 23, 2005·Anesthesia and Analgesia·Sabine Himmelseher, Marcel E Durieux
Jun 30, 2016·Therapeutic Advances in Psychopharmacology·John MullerSrinivas Pentyala
Nov 21, 2019·European Archives of Psychiatry and Clinical Neuroscience·Upinder KaurSankha Shubhra Chakrabarti
Mar 26, 2008·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jan 13, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Keiko M TarquinioUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators Network
Sep 3, 2020·General Psychiatry·Abdullah Mohammed Ramadan, Islam Ahmed Mansour
Mar 15, 2006·CNS Drugs·Kim Wolff, Adam R Winstock
May 25, 2004·Anesthesia and Analgesia·W NagelsE Vandermeersch
Jun 15, 2007·Veterinary Anaesthesia and Analgesia·Renata B RossettiRodrigo S Ferreira da Cruz

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