PMID: 9437663Jan 23, 1998Paper

S-100 proteins in trimethyltin-induced neurodegeneration in the rat hippocampus. An immunochemical and immunocytochemical study

Molecular and Chemical Neuropathology
P VinesiFabrizio Michetti

Abstract

After acute trimethyltin (TMT) intoxication (21 d after a single i.p. injection at a dose of 8 mg/kg) the histological, immunohistochemical, and immunochemical investigation of adult rat hippocampus showed a distinct pattern of neuronal loss, and an increase in both glial fibrillary acidic protein- (GFAP) immunoreactive cells and GFAP concentration, as expected. S-100-immunoreactive cells also increased markedly, whereas the concentration of S-100 increased even more than that of GFAP. The data show that S-100 is an index of glial reaction to damage after TMT intoxication and suggest the potential usefulness of exploring the possibility that it may play a role in induced neurodegenerative processes.

References

Jan 1, 1992·Neurobiology of Aging·D R MarshakW S Griffin
Nov 10, 1992·Biochimica Et Biophysica Acta·S W BargerL J Van Eldik
Jan 1, 1990·Acta Neuropathologica·F MichettiL Lauriola
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Feb 1, 1970·Journal of Neurochemistry·J E ZuckermanL Levine
Nov 14, 1984·Biochemical and Biophysical Research Communications·L J Van Eldik, S R Wolchok
May 1, 1994·Neuroscience·M A MariggióG Fanó
May 1, 1995·Progress in Neurobiology·G FanòP Calissano
Jul 1, 1995·Journal of Neurochemistry·W S GriffinL J Van Eldik
Sep 29, 1994·Biochimica Et Biophysica Acta·L J Van Eldik, W S Griffin
Mar 1, 1993·Journal of Toxicology and Environmental Health·M Aschner, R M LoPachin
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·R E MrakW S Griffin
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

❮ Previous
Next ❯

Citations

May 16, 2002·Experimental Neurology·Maria Concetta GelosoFabrizio Michetti
Feb 9, 2002·Brain Research. Molecular Brain Research·Rita BusinaroFabrizio Michetti
Aug 5, 2003·Journal of Neuroscience Research·Kai Wang, Wolfgang Walz
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pavle R AndjusGoran Bacić
Jun 30, 2005·Journal of Neuroscience Research·Camilla RealiValeria Sogos
Apr 26, 2007·Neurochemical Research·Maria Concetta GelosoFabrizio Michetti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.