S-adenosyl-L-methionine for alcoholic liver diseases

The Cochrane Database of Systematic Reviews
A Rambaldi, C Gluud

Abstract

Alcohol is a major cause of liver disease and disrupts methionine and oxidative balances. S-adenosyl-L-methionine (SAMe) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione, the main cellular antioxidant. Randomised clinical trials have addressed the question whether SAMe may benefit patients with alcoholic liver diseases. To evaluate the beneficial and harmful effects of SAMe for patients with alcoholic liver diseases. We searched The Cochrane Hepato-Biliary Group Controlled Trials Register (May 2005), The Cochrane Central Register of Controlled Trials in The Cochrane Library (Issue 2, 2005), MEDLINE (1950 to May 2005), EMBASE (1980 to May 2005), and Science Citation Index Expanded (searched May 2005). We included randomised clinical trials studying patients with alcoholic liver diseases. Interventions encompassed per oral or parenteral administration of SAMe at any dose versus placebo or no intervention. We performed all analyses according to the intention-to-treat method using RevMan Analyses provided by the Cochrane Collaboration. We evaluated the methodological quality of the randomised clinical trials by quality components. We identified nine randomised clinical trials includi...Continue Reading

Citations

Aug 10, 2011·Nature Reviews. Gastroenterology & Hepatology·José Altamirano, Ramón Bataller
Feb 15, 2011·Therapeutic Advances in Gastroenterology·Thomas H FrazierCraig J McClain
Jun 3, 2011·World Journal of Gastroenterology : WJG·Kyle J ThompsonLaura W Schrum
Feb 15, 2012·Advances in Nutrition·Charles H Halsted, Valentina Medici
Mar 8, 2014·World Journal of Gastroenterology : WJG·Maryconi M Jaurigue, Mitchell S Cappell
Mar 10, 2017·Gut and Liver·Felix StickelRamon Bataller
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Ilaria GaliziaAllan H Young
May 26, 2010·Alimentary Pharmacology & Therapeutics·G BjelakovicC Gluud
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Eric S OrmanRamon Bataller
Aug 23, 2011·Pharmacological Reports : PR·Karl-Josef GundermannMarek Droździk
Jun 17, 2011·The Cochrane Database of Systematic Reviews·Giuseppe FedeAndrew K Burroughs
Oct 21, 2006·The Cochrane Database of Systematic Reviews·A Rambaldi, C Gluud
Jul 10, 2007·The American Journal of Clinical Nutrition·Vishnudutt PurohitSamir Zakhari
Nov 1, 2017·World Journal of Gastroenterology : WJG·Sukhpreet SinghKusum K Kharbanda
Dec 31, 2014·World Journal of Gastroenterology : WJG·Elisabetta CeniAndrea Galli
Jan 1, 2016·Hepatic Oncology·Iain H McKillopKyle J Thompson
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Oct 30, 2012·Clinics in Liver Disease·Garmen A Woo, Christopher O'Brien

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