S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis

PloS One
Tao GuoQuanyan Liu

Abstract

It has been well established that S-adenosyl-L-methionine (SAMe) is the principal methyl donor in methyltransferase reactions and that SAMe supplementation restores hepatic glutathione (GSH) deposits and attenuates liver injury. However, the effectiveness of SAMe therapy in chronic liver disease has not been adequately addressed. We searched globally recognized electronic databases, including PubMed, the Cochrane Database and EMBASE, to retrieve relevant randomized controlled trials (RCTs) of chronic liver disease published in the past 20 years. We then performed a systematic review and meta-analysis of the enrolled trials that met the inclusion criteria.The results showed that twelve RCTs from 11 studies, which examined 705 patients, were included in this research. For liver function, certain results obtained from data synthesis and independent comparisons demonstrated significant differences between the levels of total bilirubin (TBIL) and aspartate transaminase (AST). However, no studies identified significant differences regarding alanine transaminase (ALT) levels. An analysis of the adverse events and long-term prognosis also indicated no significant differences between the SAMe and the placebo groups. In a subgroup analys...Continue Reading

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Citations

Jan 9, 2017·The Veterinary Clinics of North America. Small Animal Practice·Nick Bexfield
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson
May 27, 2020·Veterinary Medicine International·Andrea MarchegianiMatteo Cerquetella
Aug 22, 2020·World Journal of Hepatology·Huey K TanAshwin D Dhanda
Sep 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura VerganiNiccolò Miraglia
Apr 11, 2018·Frontiers in Chemistry·Nils-Ole FriedrichJohannes Kirchmair
Mar 23, 2021·Toxicology Mechanisms and Methods·Shuman ZhangZhihu Zhang

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